Misumi (三隅町, Misumi-cho) is located in the west of Shimane prefecture.
From Hiroshima to Hamada
There are daily buses from Hiroshima to Hamada. It takes about two hours.
There are overnight buses to Hamada from Osaka or Tokyo.
From Hamada to Misumi
Car
30 Minutes from Hamada IC via Masuda
40 Minutes from Hagi-Iwami Airport
Train
You can get to Mihomisumi Station(the nearest station) by JR Sanin-Line.
It takes 20 minutes from Hamada by local train.
It takes 5 minutes by car or 15 minutes by 100Yen-bus to get to the heart of Misumi from Mihomisumi
See also: http://www.h-tourism.com/accessmap.html